CMPK

CMPK1
Cấu trúc được biết đến
PDB	Tìm trên Human UniProt: PDBe RCSB
Danh sách mã id PDB
	1TEV
Mã định danh
Danh pháp	CMPK1, CK, CMK, CMPK, UMK, UMP-CMPK, UMPK, cytidine/uridine monophosphate kinase 1
ID ngoài	OMIM: 191710 HomoloGene: 32308 GeneCards: CMPK1
Số EC	2.7.4.6
Mẫu hình biểu hiện RNA
	Thêm nguồn tham khảo về sự biểu hiện
Bản thể gen
Chức năng phân tử	• transferase activity; • nucleotide binding; • uridylate kinase activity; • kinase activity; • nucleobase-containing compound kinase activity; • uridine kinase activity; • nucleoside diphosphate kinase activity; • ATP binding; • cytidylate kinase activity; • nucleoside monophosphate kinase activity;
Thành phần tế bào	• tế bào chất; • cytosol; • extracellular exosome; • nhân tế bào; • Hạch nhân;
Quá trình sinh học	• nucleobase-containing small molecule interconversion; • Phosphoryl hóa; • nucleoside diphosphate phosphorylation; • pyrimidine ribonucleotide biosynthetic process; • pyrimidine nucleotide biosynthetic process; • 'de novo' pyrimidine nucleobase biosynthetic process; • nucleoside triphosphate biosynthetic process; • nucleobase-containing compound metabolic process; • nucleoside monophosphate phosphorylation; • UMP biosynthetic process;
	Nguồn: Amigo / QuickGO
Gen cùng nguồn
	51727
	n/a
	ENSG00000162368
	n/a
	P30085
	n/a
	NM_001136140; NM_016308; NM_001366135
	n/a
	NP_001129612; NP_057392; NP_001353064
	n/a
	Wikidata
Xem/Sửa Người

UMP-CMP kinase là enzyme ở người được mã hóa bởi gen CMPK1.^[2]^[3]

Chức năng

Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) xúc tác quá trình vận chuyển phosphoryl từ ATP đến UMP, CMP và deoxy-CMP (dCMP), kết quả là hình thành ADP và nucleoside diphosphate tương ứng. Những nucleoside diphosphate này cần thiết cho sự tổng hợp axit nucleic tế bào.^[3]^[4]

Tham khảo

^ “Human PubMed Reference:”.
^ Van Rompay AR, Johansson M, Karlsson A (1999). “Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme”. Molecular Pharmacology. 56 (3): 562–9. PMID 10462544.
^ ^a ^b Bản mẫu:EntrezGene
^ Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). “Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates”. Cancer Research. 62 (6): 1624–31. PMID 11912132.

Liên kết ngoài

Vị trí bộ gen CMPK1 ở người và thông tin chi tiết về gen CMPK1 có sẵn trên UCSC Genome Browser.

Đọc thêm

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Pearman AT, Castro-Faria-Neto HC, McIntyre TM, Prescott SM, Stafforini DM (2001). “Characterization of human UMP-CMP kinase enzymatic activity and 5′ untranslated region”. Life Sciences. 69 (20): 2361–70. doi:10.1016/S0024-3205(01)01322-4. PMID 11681623.
Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). “Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates”. Cancer Research. 62 (6): 1624–31. PMID 11912132.
Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D (2003). “Reaction of human UMP-CMP kinase with natural and analog substrates”. European Journal of Biochemistry. 270 (8): 1784–90. doi:10.1046/j.1432-1033.2003.03537.x. PMID 12694191.
Segura-Peña D, Sekulic N, Ort S, Konrad M, Lavie A (2004). “Substrate-induced Conformational Changes in Human UMP/CMP Kinase”. Journal of Biological Chemistry. 279 (32): 33882–9. doi:10.1074/jbc.M401989200. PMID 15163660.
Hsu CH, Liou JY, Dutschman GE, Cheng YC (2004). “Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase is Differentially Regulated by ATP and Magnesium”. Molecular Pharmacology. 67 (3): 806–14. doi:10.1124/mol.104.006098. PMID 15550676.
Wickham L, Benjannet S, Marcinkiewicz E, Chretien M, Seidah NG (2005). “Beta-Amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin”. Journal of Neurochemistry. 92 (1): 93–102. doi:10.1111/j.1471-4159.2004.02840.x. PMID 15606899.
Topalis D, Kumamoto H, Amaya Velasco MF, Dugué L, Haouz A, Alexandre JA, Gallois-Montbrun S, Alzari PM, Pochet S, Agrofoglio LA, Deville-Bonne D (2007). “Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives – a screening based on affinity for the UMP-CMP binding site”. FEBS Journal. 274 (14): 3704–14. doi:10.1111/j.1742-4658.2007.05902.x. PMID 17608725.
Gagyi C, Bucurenci N, Sîrbu O, Labesse G, Ionescu M, Ofiteru A, Assairi L, Landais S, Danchin A, Bârzu O, Gilles AM (2003). “UMP kinase from the Gram-positive bacterium Bacillus subtilis is strongly dependent on GTP for optimal activity”. European Journal of Biochemistry. 270 (15): 3196–204. doi:10.1046/j.1432-1033.2003.03702.x. PMID 12869195.
Ofiteru A, Bucurenci N, Alexov E, Bertrand T, Briozzo P, Munier-Lehmann H, Gilles AM (2007). “Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase”. The FEBS Journal. 274 (13): 3363–73. doi:10.1111/j.1742-4658.2007.05870.x. PMID 17542990.

Bài viết về một gen trên nhiễm sắc thể 1 ở người này vẫn còn sơ khai. Bạn có thể giúp Wikipedia mở rộng nội dung để bài được hoàn chỉnh hơn.

[1] “Human PubMed Reference:”.

[pmid10462544-2] Van Rompay AR, Johansson M, Karlsson A (1999). “Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme”. Molecular Pharmacology. 56 (3): 562–9. PMID 10462544.

[entrez-3] Bản mẫu:EntrezGene

[4] Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). “Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates”. Cancer Research. 62 (6): 1624–31. PMID 11912132.

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